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The primary outcome of both studies was the change from baseline to week 78 in Clinical Dementia Rating Sum of Boxes (CDR-SB) scores

These improvements are often seen in before & after comparisons taken over several weeks or months

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Although each of these signaling pathways can independently control the expression of antioxidant genes, they are also all interconnected, demonstrating the intricate regulatory system that governs the response to oxidative stress

doi: 10.1189/jlb.0406249 138 PettersenJSFuentes-DuculanJSuarez-FarinasMPiersonKCPitts-KieferAFanLet al