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AGC Target MSMS: 5e5 with positive polarity

5D, Figure S15A and B), indicating its capacity to preserve mitochondrial integrity and sustain energy metabolism homeostasis

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For instance, selective degradation of HDAC6, HDAC8 and SIRT2 by PROTACs has been reported to inhibit tumor progression in vitro [176,177,178]

The peptides were analyzed by data-dependent acquisition (DDA) in positive mode using Orbitrap MS analyzer for precursor scan at 120,000 FWHM from 400 to 2000 m/z and ion-trap MS analyzer for MS/MS scans in top speed mode (3-s cycle time) with dynamic exclusion settings (repeat count one and exclusion duration 15 s)

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