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The resolved and predicted structure are highly similar

This superoxide is rapidly converted into hydrogen peroxide (HO), which, in the presence of Fe 2+ , generates highly reactive hydroxyl radicals (OH) through the Fenton reaction

After blocking with 5% nonfat dry milk in TBS-Tween for 12 h at room temperature, blots were incubated with appropriate primary antibodies overnight at 4 C

In particular, Trastuzumab emtansine (Kadcyla, T-DM1) that comprises an HER2-targeted antibody, a non-cleavable linker and a microtubule disrupting agent as the payload, and Trastuzumab deruxtecan (Enhertu, T-DXd), which is composed of a HER2-targeted antibody, a cleavable linker and a Topoisomerase I inhibitor as payload

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TAAR1-stimulated RhoA Activation Mediates AMPH-stimulated Internalization of Both Catecholamine Transporters Using these primary culture models, we re-examined the mechanism of action of AMPH