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demonstrated that the modification of PBAE side chains with caprolactone enabled mRNA delivery to the spleen through intravenous administration [174]

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These derivatives exhibit enhanced potency and selectivity, enabling them to effectively inhibit cancer cell proliferation, migration, and metastasis through mechanisms such as the activation of the PERK/eIF2 /CHOP pathway, induction of ER stress, and lysosome-dependent cell death

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Diabetes Care 33 , 26972708 (2010)

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doi: 10.1155/2014/523924 22

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18 This triple therapy combines one potentiator (ivacaftor) with two correctors (elexacaftor and tezacaftor) to increase CFTR protein quantity and function

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