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Acknowledgments The authors would like to thank the patients for their participation in this study and permission to publish

Moving beyond the traditional fragmented perspectives that have limited our understanding and management of the disease, our analysis of current information on ME/CFS represents a significant paradigm shift by synthesising the diseases multifactorial origins into a cohesive model

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While the experimental models employed in PD have shown connections to human health, it remains a daunting task to translate mechanisms of action observed in in vitro and in vivo studies of natural compounds to clinical outcomes in human trials, where it is a critical step in drug development

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