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This suggests that DNA methylation is not static but serves as a highly adaptable tool for epigenetic regulation (Smith and Meissner, 2013)

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The role of the Cys residues of the N-terminal thiol region (NTR) has not been investigated by mutation but constructs of human ERO1A and yeast ERO1 lacking the NTR are often used for functional assays (Cabibbo et al., 2000

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The obtained results are typical for old animals (Goshovska et al., 2009) and indicate calcium overload of cardiomyocytes, energy deficit, and intensification of oxidative metabolism and support the data about the excessive formation of ROS in aged rat heart mitochondria (Table 2)