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Moors MA, Stull TL, Blank KJ, Buckley HR, Mosser DM

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Emerging therapies: novel mechanistic targets arising from pathobiology In recent years, significant advancements have been achieved in the treatment of IBD, particularly with the introduction of biologic agents, which have substantially improved disease management

Urticaria presents as pruritic, pale, or erythematous weals

Other conditions known to influence expression of GCLC at the transcriptional level include treatments with antioxidants such as butylated hydroxyanisole [74,75], 5,10-dihydroindeno [1,2-b]indole and tert-butyl hydroquinone (TBH) [44,76,77], inducers of Phase II detoxifying enzymes such as -naphthoflavone (-NF) [78], formation of Michael reaction acceptors (containing an electrophilic electron-deficient center that is susceptible to nucleophilic attack) by treatment with diethyl maleate (DEM) to produce GSH conjugates [75], heat shock [79], zinc [80], melatonin [81], curcumin [82], and lipid peroxidation products such as 4-hydroxynonenal (4-HNE), 15-deoxy- 12,14 -prostaglandin J 2 (15d-PGJ 2 ) [8386], trivalent arsenite (As 3+ ) [87], and ajoene, a major compound in garlic extracts [88]

Mice were weighed and monitored using scoring charts for body condition, behavioural and clinical signs of leukaemic engraftment