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On a different angle, when subjected to DEN-induced hepatocarcinogenesis, overexpression of PGC-1 renders mice more prone to hepatocarcinoma development possibly by enhancing the expression of genes involved in fatty acids and triglycerides synthesis as well as by limiting ROS accumulation via increased antioxidant response 12

2 Chemical method Many chemical approaches have been suggested to produce NPs [228]

Alzheimers Dement (N Y) 8 (2022): e12268

43 IndiveriC.PochiniL.OppedisanoF.TonazziA

and its medicinal utilization

In addition, cisplatin is known to deplete mitochondrial antioxidant enzyme activities, a finding that has been verified by cisplatin-induced increases in lipid peroxidation and GSSG/GSH ratio 25,26,27,28