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Vitamin B12 is water-soluble, so excess amounts are typically excreted through urine

(3) It minimizes sustained membrane depolarization, raises the threshold for migraines, inhibits the release of CGRP and glutamate from the trigeminal vascular nerve endings, blocks high-voltage activated Ca 2+ channels, and reduces or prevents the release of neurotransmitters and vasoactive peptides (Dodick, 2018)

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R2 : How well do predictions from global models compare to observed values at locations not used in the map calibration/training, i.e., what is the expected prediction error at unvisited locations

Brazil nuts, sardines, and eggs are excellent sources

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