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Effect of selenium status on thyroid disease Selenium deficiency has been associated with a number of adverse thyroid conditions, including hypothyroidism, subclinical hypothyroidism, enlarged thyroid ( Reference Derumeaux, Valeix and Castetbon 74 Reference Rayman, Duntas, Luster, Duntas and Wartofsky 77 ) , thyroid cancer ( Reference Schmutzler, Mentrup and Schomburg 67 , Reference Rayman, Duntas, Luster, Duntas and Wartofsky 77 Reference Lin, Kuo and Chiang 79 ) and AITD, including HT ( Reference Wu, Rayman and Lv 75 , Reference Rayman, Duntas, Luster, Duntas and Wartofsky 77 ) and GD ( Reference Rayman, Duntas, Luster, Duntas and Wartofsky 77 , Reference Bulow Pedersen, Knudsen and Carle 80 )

doi: 10.1371/journal.pone.0180594 102 SheC.ShiG

Clinical evaluation of Guilu Erxian Jiao in treating perimenopausal syndrome

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The diversity of proposed effects is vast, and so is the quality of the evidence

GABAergic System: The peptide has been shown to potentiate the activity of the Gamma-Aminobutyric Acid (GABA) system, the primary inhibitory network in the mammalian brain