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The rats were treated with PNPS-1 at different doses which reduced very-low-density: lipoprotein/low-density lipoprotein cholesterol, triacylglycerol, phospholipids, and increased the atherogenic index and high-density lipoprotein cholesterol in the serum

HMEC1-hFcRn cells 63 were maintained in MCDB 131 medium (ThermoFisher) supplemented with 10% HI-FCS, 2 mM L-glutamine, 25 g/mL streptomycin, 25 U/mL penicillin, 10 ng/mL mouse epidermal growth factor (mEGFR) (Peprotech) and 1 g/mL hydrocortisone

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3503-C A PHASE 2a, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY EVALUATING THE SAFETY, TOLERABILITY, EFFICACY, AND PHARMACOKINETICS OF INT-787 IN SUBJECTS WITH SEVERE ALCOHOL-ASSOCIATED HEPATITIS: STUDY DESIGN, OBJECTIVES, AND NOVEL ASSESSMENTS Thomas Capozza, Steven Lauder, Sam Madison and Jennifer Callahan, Intercept Pharmaceuticals, Inc., Morristown, NJ Background: Severe alcohol-associated hepatitis (sAH) is the most acute and serious form of alcohol-associated liver disease