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Because MTHFR gene variations impair the bodys ability to convert B vitamins, methylated forms of B vitamins are considered the most bioavailable as they dont need any conversion by the body Consider high doses: you might need significant doses of methylcobalamin to treat a deficiency

In both male and female Gsta4 / mice, GST activities toward 4-HNE were substantially lower (~75% decrease) compared to WT mice (Fig

2001 [8] Lenton KJ, San AT, Therriault H, Cantin AM, Payette H, Wagner JR

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[15] This suggests that 600 mg/day may be an optimal upper-limit dose for most patients in terms of balancing efficacy and tolerability