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Following the positive REDEFINE 1 Phase 3 data (published June 2025, PMID: 40544433), Novo Nordisk announced plans to file regulatory applications for CagriSema for obesity in the United States (FDA), European Union (EMA), and other major markets in 20252026

Accordingly, we hypothesized that p53 stabilization conserved GSH and suppressed ferroptosis by reducing mitochondrial activity

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These findings are accompanied by elevated markers of oxidative stress and redox imbalanceconditions known to impair neurogenesis and alter synaptic function

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