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For the GSSCys assays, either GSH was varied between 50 M and 2.0 mM at fixed GSSCys concentrations (25, 50, 100 and 150 M) or GSSCys was varied between 25 and 200 M at fixed concentrations of GSH (0.05, 0.1, 0.2, 0.3 and 1.0 mM for ScGrx7 or 0.3, 0.5, 1.0 and 2.0 mM for PfGrx)

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J Biol Chem 276: 1616816176 KloppelC,SuzukiY,KojerK,PetrungaroC,LongenS,FiedlerS,KellerS,RiemerJ (2011) Mia40dependent oxidation of cysteines in domain I of Ccs1 controls its distribution between mitochondria and the cytosol

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Human induced pluripotent [37, 38] or hematopoietic [39, 40] stem cell-based models overcome the translational problems related to the BBB