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Further REIMAGINE results presented at the ADA meeting in June 2026 reinforced that signal across diverse patient groups

When bowel changes occur during B12 supplementation, they are typically attributable to other factors such as concurrent medications, dietary changes, or the presence of iron or calcium in multivitamin formulations

This mechanism naturally limits absorption when B12 is consumed in large quantities, with excess amounts typically eliminated through the kidneys without causing harm

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