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1 for baseline before treatment start) receiving either etomoxir (Wt+R+E) or vehicle (Wt+R+V) alternating with rotenone (Fig

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Clinical studies also support these findings, suggesting that high levels of butyrate and propionate may enhance the function of immunosuppressive cells, such as Treg cells, and alter the immune microenvironment, thereby limiting the effectiveness of CTLA-4 inhibitors (Coutzac et al., 2020)