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In vitro studies and aging rat models, PPAR signaling has demonstrated a significant role in anti-oxidative stress and has some vascular enhancement effects (Zhang et al., 2008

Mechanistically, ammonium disrupts acidic compartments, as indicated by reduced LysoTracker staining, likely impairing the pH-dependent maturation of perforin (79)

doi: 10.3389/fncel.2020.00231 289 HambrightWSFonsecaRSChenLNaRRanQ

The expression of genes downstream of IL-17 was suppressed after Gln blockade, and the downregulated genes were enriched in the STAT3-related pathway (50)