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A pivotal study that highlighted the crucial role of thiamine as an essential nutrient for infant development and discussed how TD phenotype may be confused or overlooked with other diseases was based on an epidemiological investigation on 24- to 39-month-old children presenting repeated vomiting, irritability, and lethargy, without major neurological abnormalities

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3a, we show that one of the small molecules that was a positive hit in the parent TR-FRET assay, ENDO3, abolished CpG-mediated activation of TLR9