ginko coq10 glutathione Nrf2/FSP1/CoQ10 axis-mediated ferroptosis is involved in sodium aescinate-induced nephrotoxicity Frontiers | Neuroprotective effects of

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(2016) found that withaferin A is a strong inducer of Nrf2, a transcription factor that controls the production of antioxidant enzymes in response to oxidative stress through activation of the PTEN/PI3K/Akt pathway [146]

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Figure 3 Natural products inhibit or degrade GPX4-induced ferroptosis Glutathione peroxidase 4 (GPX4) is the only enzyme in cells that can reduce lipid peroxides to lipids, and GPX4 plays a crucial role in ferroptosis (24)

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