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Intelligently thermoresponsive flower-like hollow nano-ruthenium system for sustained release of nerve growth factor to inhibit hyperphosphorylation of tau and neuronal damage for the treatment of Alzheimer's disease

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In our opinion, when considering a new compound for clinical testing, it is important to have in vivo and in vitro studies confirming positive effects suggested by gene profiling as well as safety

GI side effects, especially nausea, were common in the early studies at higher doses

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2004 Apr;137(4):389-91