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For instance, curcumin has been found to stimulate the expression of glutamate-cysteine ligase , the enzyme responsible for initiating glutathione synthesis

Possible Side Effects While peptides are generally considered safe, some side effects may still occur: Injection Site Reactions Since most peptides are administered via subcutaneous injection, this can lead to redness, swelling, bruising, or irritation at the injection site

Multiple copper chelators and copper ionophore have exhibited good anti-tumor properties, indicating that targeting the copper transport system can be used for tumor treatment or increasing the sensitivity of other anticancer drugs

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To validate these findings, future work should focus on randomized controlled trials testing integrated lifestyle interventions using functional foods and exercise, with endpoints such as recurrence, inflammation, and quality of life and personalized, omics-guided strategies to match specific dietary and physical activity regimens to individual epigenetic or metabolic profiles

5.1 Mechanism of intranasal delivery Since William Frey II proposed intranasal administration in 1991 (Frey, 1991), this technique has emerged as a novel, non-invasive delivery system, bypassing the BBB and the systemic first-pass effect, allowing rapid onset of action