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Specific sodium-independent glucose transporters (GLUTs) facilitate transport across the BBB: GLUT1 is largely expressed in endothelial cells and astrocytes, whereas GLUT3 and GLUT4 are localized to neurones ( While glucose is the primary metabolic fuel, the brain may actively transport and use alternate substrates through specialized carrier proteins

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While motor impairments motor can impair cognitive performance in the MWM, we could rule motor deficits as a confounding factor on the cognitive parameters in the MWM as swimming speed did not differ between Tg4-42 and WT mice at any age tested