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More importantly, these conjugates show an extremely long duration of action when combined with enhanced stabilization modification chemistry, e.g., ESC or ESC-plus (Fig

Nat Rev Immunol 24:858877 Beil WJ, Meinardus-Hager G, Neugebauer DC, Sorg C (1992) Differences in the onset of the inflammatory response to cutaneous leishmaniasis in resistant and susceptible mice

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If the second sample shows a level of IgG that is four times higher than the first, it strongly supports a diagnosis of an active or recent infection