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These findings suggested that SP regulated the NRF2 expression mainly via the modulation of KEAP1

The high MDA level in the untreated liver homogenate may further suggest redox imbalance

doi: 10.3390/cells11060932 264 Souza-FernandesA

One is that GSSG and GS-X produced in cardiomyocytes are pumped out by multidrug resistance protein 1 (MRP1), preventing GSSG or GS-X accumulation in cardiomyocytes [33, 34], and subsequently enter the -glutamyl cycle