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Studio di Badenhorst et al

Glycine betaine is the result of a two-step oxidation of choline by betaine aldehyde which is a toxic intermediate ( + dependent betaine dehydrogenase (BADH) ( in vivo varies among plant species and is between 40 and 400 mol g-1 (DW) in natural accumulation under stress conditions (Wani et al., 2013)

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Subsequently, bioinformatics analyses was perfromed by OmicStudio tools ( RNA-sequencing (RNA-seq) CaOx-exo and Ctrl-exo treated macrophages were subjected to high-throughput RNA sequencing (Wayenbiotech, China)