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Reported side effects Mild local irritation or discomfort at the injection site Headache (typically mild and short-lived) Nausea or dizziness in some patients Sweating Mild fever more commonly reported in post-stroke use, generally manageable with standard antipyretics Contraindications Cerebrolysin is not recommended for individuals with: Active epilepsy or seizure disorders Severe renal (kidney) impairment Known hypersensitivity to any component of the formulation Note: A 2023 Cochrane review noted a potentially higher rate of spontaneous adverse events in some stroke trial subgroups

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Ice crystal formation physically damages the peptide structure, creating aggregation and reducing biological activity

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