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NADs are a class of gene therapy agents based on DNA, RNA, or synthetic oligonucleotide analogs

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FFA treatment has been linked to increased survival rates in human studies and in vivo models [57]

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These varying observations highlight the critical distinction between enzyme concentration and actual catalytic activity, as evidenced in other inflammatory conditions where plasma SOD1 concentration increased while total activity remained unchanged (Sciskalska et al., 2020)