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The released inhibitor not only inhibited the influx of pyruvate into the mitochondria but also effectively blocked the tricarboxylic acid (TCA) cycle, which is fueled by glucose and lactate, thereby disrupting aerobic respiration and alleviating tumor hypoxia (Figure 6B)

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The trial measured ISQ immediately after placement and at 3 months, and reported a significantly larger ISQ increase for photofunctionalized implants (mean change 4.4 1.89) compared with non-photofunctionalized implants (2.6 1.17), together with a higher OSI (1.42 0.62 vs

Due to hormonal changes, she can no longer become pregnant or bear children

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