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Competing Interests The authors declare the following competing interests: [Donghoon Kang and Chin-Ju Park] are listed as an inventor on a pending patent application related to A peptide inhibitor for senescent cell elimination, and a use thereof, filed by [Gwangju institute of science and technology] under application number KR10-2024-0086615

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A few commenters emphasized the importance of implementing measures that use validated, flexible, and interdisciplinary tools, such as the Patient-Reported Outcomes Measurement Information System (PROMIS), World Health Organization Well-Being Index (WHO-5), Patient Health Questionnaire-9 ( (PHQ-9), Canadian Occupational Performance Measure (COPM), Occupational Self-Assessment (OSA), and Self-Management Ability Scale (SMAS), that capture individualized outcomes including participation, resilience, and quality of life