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As in celiac disease, the fast-acting or innate immune system is activated in non-celiac gluten sensitivity, causing moderate inflammation of the intestinal lining

Walter et al., 2021)

191 Once-daily administration of roflumilast significantly improves forced expiratory volume in 1 s and decreases exacerbations, particularly in patients with severe disease, 192,193 but has side effects such as nausea, vomiting and headache

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Based on its pathophysiological mechanisms, DM is classified into type 1 diabetes mellitus (T1DM) and T2DM, with T2DM accounting for 90% of cases [2]