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Research suggests DSIP modulates GABAergic and glutamatergic neurotransmission, interacts with the hypothalamic-pituitary-adrenal (HPA) axis to reduce cortisol and ACTH levels, and may influence circadian rhythm regulation through effects on melatonin and serotonin pathways

G., & Shukitt-Hale, B

Common reasons for deficiency include: Low intake particularly diets low in whole grains, legumes, leafy greens or animal products Gut health issues like low stomach acid, SIBO, coeliac disease, IBD, or other factors affecting absorption Medications such as the contraceptive pill, metformin or antacids, which can deplete B vitamins Chronic stress increases demand for certain b vitamins, including B5 and B6 Vegan or vegetarian diets higher risk of B12 deficiency, which can be corrected through supplementation Genetic reasons some mutations on certain genes can increase a persons need for B vitamins This is why I always recommend testing before supplementing

Molecular basis for the action of a dietary flavonoid revealed by the comprehensive identification of apigenin human targets

Just a few minutes of intentional breathwork and mindfulness a day can be a great place to start

Studies show that approximately 1% of a high-dose B12 supplement is absorbed through passive diffusion along the entire gastrointestinal tract, completely bypassing the need for Intrinsic Factor or perfect stomach acid levels