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Oral administration of myricetin significantly reduces Fe 2+ levels in the substantia nigra of PD rats, inhibits neuronal ferroptosis, decreases ROS production, downregulates malondialdehyde (MDA) and -synuclein (-Syn) expression, elevates GSH levels, and ameliorates motor deficits

The excitatory receptor ser-1 is expressed in RIA and RIC neurons, among other locations 35,73,74,77 , and regulates nociception by acting in RIC neurons 74

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Bockeria et al., 2013)