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In the human eye, the composition and biomechanical properties (rigidity, elasticity and topology) of the ECM within the Trabecular Meshwork/Schlemms Canal (TM/SC) contribute to the regulation of intraocular pressure (IOP) and the pathogenesis of glaucoma (Keller and Peters, 2022)

(123) also found that Clostridium IV and XIVa isolated from healthy mice increased the number of systemic and lamina propria Treg cells when transplanted into germ-free mice, which in turn affected osteoclast genesis through the secretion of IL-4, IL-10, and TGF-