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Inhibitory effect of dietary iron deficiency on inductions of putative preneoplastic lesions as well as 8-hydroxydeoxyguanosine in dna and lipid peroxidation in the livers of rats caused by exposure to a choline-deficient l-amino acid defined diet

in contrast, preclinical models of BIPN did not demonstrate anti-allodynic effects with diclofenac and amitriptyline treatment (Yamamoto et al., 2015)

Further advancing this field, the clinical trial NCT05218903 is evaluating subcutaneous versus intravenous delivery of lecanemab in early Alzheimers disease

Antioxid Redox Signal 26(8):364387

Limitations of current evidence Despite compelling biological rationale, several limitations remain