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The yakuchinones inhibited the iNOS and COX-2 expression as well as TNF- mRNA expression in mouse skin treated with 12-O-tetradecanoylphorbol-13-acetate (TPA)

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All injectable dosing discussions should be framed accordingly and kept clearly distinct from the topical evidence base

2009;4:e6744

That said, many experienced researchers run new combinations from the start with sufficient monitoring and baseline tracking to draw useful conclusions