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TFA was used as an ion-pair reagent, which provides the best separation conditions in the parameters mentioned above, and at a concentration of 80 mM it is also an extremely suitable electrolyte for the detection of thiols

[DOI] [PMC free article] [PubMed] [Google Scholar] 79.Cerretelli G, Ager A, Arends MJ, Frayling IM

Damage to a cell's DNA is particularly harmful because DNA is the blueprint for protein production and unlike other molecules it cannot simply be replaced by re-synthesis