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174,175 Oxidative stress, proteasome dysfunction, and protein aggregation, changes that frequently occur during aging, have been implicated in the pathogenesis of PD

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Furthermore, chronic pulmonary diseases, such as COPD, are often associated with a significant oxidative/antioxidant imbalance [476]

Some call it adrenal fatigue (though the medical community loves to say, Thats not a thing!)

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Future works searching for genetic and post-translational modifications affecting FLNA expression and function, as well as for a possible involvement of other cytoskeleton proteins, might help to clarify the complex mechanisms involved in pituitary tumors pharmacological resistance