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Furthermore, in cultured genital skin fibroblasts (if available) the conversion of testosterone to 5-dihydrotestosterone can be assessed and is an option for establishing a defective enzyme

It is clear that ARs interactions with its protein network, as well as the type of ARE that it binds, can markedly influence the transcriptional output from DNA-bound AR, and, thus, a one-size-fits-all mechanism by which AR regulates transcription from ARE-containing genes does not apply

10.1016/j.physbeh.2020.113020 PMID: 32574662 [DOI] [PMC free article] [PubMed] [Google Scholar] [208].Villavasso S, Shaw C, Skripnikova E, Shah K, Davis JF, Sirohi S

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Lett Drug Des Discov

[16] Around 2016, the United States and Canada reported a dramatic increase in shipment of carfentanil and other strong opioid drugs to customers in North America from Chinese chemical supply firms