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doi: 10.3390/MOLECULES201119654 276 LongXZhaoXWangWZhangYWangHLiuXet al

conducted a randomized double-blind crossover trial and found that acute oral supplementation of 1.5 g Phe prior to moderate-intensity aerobic exercise in healthy males led to a 12% reduction in the respiratory exchange ratio, alongside significant increases in plasma glycerol (79%) and glucagon (26%) ( In addition, the Phe-derived metabolite Lac-Phe has emerged as a critical mediator in exercise-induced appetite suppression

H 2 O 2 is a key messenger molecule in redox signaling but at higher concentrations can induce oxidative damage [16, 17]

Thus, combined heterozygosity of multiple mitochondrial genes might negatively impact brain development and/or brain function, especially given the high energy demands of the brain