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Chronic IFN-I stimulation perturbs lipid metabolism and redox balance in exhausted CD8 + T cells, leading to aberrant lipid accumulation and elevated lipid peroxidation, which exaggerates metabolic and functional exhaustion of T cells (46)

Artificial mitochondria transfer: current challenges, advances, and future applications

Additionally, in patients with folic acid deficiency, the plasma levels of methionine and betaine remain unchanged, and the DMG concentration increases, which suggests that betaine, acting as a methyl-group donor, is able to compensate for folic acid deficiencies and ensure the proper functioning of the one-carbon cycle [202,203]

Evans, K

The studies by Doll et al (87) and Bersuker et al (88) report that CoQ10 can behave as a lipophilic free radical-trapping antioxidant that diminishes the accumulation of lipid peroxides and attenuates the occurrence of ferroptosis

As a central antioxidant, glutathione protects cells from the harmful effects of free radicals and supports essential cellular functions, contributing to better overall health and longevity