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It arises from an abnormally expanded CAG trinucleotide repeat encoding the elongated polyglutamine (polyQ) within exon 1 of Huntingtin ( HTT ) gene, which results in the production of toxic mutant huntingtin proteins (mHTT) that accumulate in neurons, particularly in the striatum and cortex (Genetic Modifiers of Huntingtons Disease Consortium, 2019)

Conversely, the proautophagic activity of trehalose conferred protection against CP-induced AKI but also antagonized the antitumor effects of CP (del Bello et al., 2013

Transfection can be carried out using calcium phosphate, by electroporation, by cell squeezing or by mixing a cationic lipid with the material to produce liposomes, which fuse with the cell membrane and deposit their cargo inside

doi: 10.1177/0748730420967768 137 Rijo-FerreiraFTakahashiJS

Known for its pivotal role in cellular energy production and DNA repair, this therapy is designed to enhance overall wellness, promote longevity, and address conditions associated with aging

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