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A six-month, multicenter observational study enrolled 197 stroke subjects (mean age, 81.5 years) with a progressive decline of their mental health and general confusion and/or stupor who were initially administered citicoline for 5 or 10 days (2,000 mg/day, by intravenous infusion) within a four-month period, and then for 21 days (1,000 mg/day, by intramuscular injection), repeated once after a seven-day washout period (93)

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Ozone decreases the production of pro-inflammatory cytokinesparticularly IL-6, IL-1, and TNF-which are primarily responsible for cartilage degradation

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Most patients need continued therapy to maintain benefits, though some may attempt supervised discontinuation after achieving significant metabolic improvements