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Although ATF4 may play a pro-apoptotic role under conditions of severe or prolonged stress, ATF4 is a potent stress-responsive gene thought to play a protective role by regulating cellular adaptation to adverse circumstances in the integrated stress response (ISR) [8], [9], [10]

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refdata-cellranger-arc-GRCh38-2020-A-2.0.0 was used for the snATAC-Seq experiments and refdata-gex-GRCh38-2020-A for the scRNA-Seq

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2020;8(9):e1372