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Nrf2, the master regulator of anti-oxidative responses

In the methionine cycle, methionine is activated by adenylation to S-adenosylmethionine (SAMe)

Okamura, E

Hydroxysafflor yellow a alleviates acute myocardial ischemia/reperfusion injury in mice by inhibiting ferroptosis via the activation of the HIF-1alpha/SLC7A11/GPX4 signaling pathway

Effect of fluoxetine on rat liver mitochondria

However, others propose that respiratory inhibition negatively affects ATP production via subsequent effects on mitochondrial depolarization ( Alternatively, there is the notion that NO advantageously affects mitochondrial efficiency (Pappas et al., 2023)