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Gould NS, Day BJ: Targeting maladaptive glutathione responses in lung disease

Radiotherapy has been used for many years, but current evidence demonstrates a non-inferiority of chemotherapy with less impact on fertility, hypogonadism, and onset of second malignancies [332,333,334]

102 Maintenance of a physiological (low-level) oxidative stress, also denoted as oxidative eustress, is pivotal for governing biological processes and physiological functions including cell cycle and proliferation, circadian clock, innate immunity, self-renewal of stem cells and neurogenesis

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Serotonin is then converted into N-acetylserotonin and finally into melatonin by the enzymes Serotonin-N-acetyl transferase (SNAT) and hydroxyindole-O-methyltransferase (HIOMT), respectively [142, 143, 147]

10.1056/NEJMoa1505180 N