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In addition, the treatment of nicotinamide (NAM), a form of vitamin B3, suppressed the activity of sirtuin-1 (SIRT1), a regulator of cellular stress resistance, and peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1), a key transcriptional coactivator involved in mitochondrial biogenesis and energy metabolism

In conclusion, GPX4 can affect the development of lung cancer by regulating ferroptosis

Similarly, as discussed previously, auranofin has demonstrated the ability to enhance T cell anti-tumor immunity in preclinical models and holds strong potential for repurposing as a cancer therapeutic, given its established use in rheumatoid arthritis (134)

Nat Commun (2021) 12(1):1940

TengXShanZLiCYuXMaoJWangWet al

Antioxidant activity with increased endogenous levels of vitamin C, E, and A following dietary supplementation with a combination of glutathione and resveratrol precursors