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Before puberty, female children already have slightly but significantly higher levels of total cholesterol (TC) and LDL-C than male children, suggesting an intrinsic metabolic difference independent of adult sex hormone levels ( 4.2 Adipose tissue distribution and menopausal transition The distribution pattern of adipose tissue is another key sex-differentiated factor

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REFERENCES Bick JA, Setterdahl AT, Knaff DB, Chen Y, Pitcher LH, Zilinskas BA, Leustek T (2001) Regulation of the plant-type 5-adenylyl sulfate reductase by oxidative stress