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As a treatment for facial paralysis, especially synkinesis, BOTOX treats a variety of conditions, including: Excessive muscle tightness around the eye (blepharospasm) Excessive and constant facial muscle contraction (facial spasticity or hypertonicity) Involuntary facial movement (synkinesis), most commonly oral-ocular synkinesis, in which the eye closes when attempting to smile or eat or ocular-oral synkinesis, in which the mouth moves when attempting to close the eye

Control mice received an AAV-shNC construct (pscAAV-U6-shNC-CMV-EGFP-tWPA)

19 FDA issued warning letters to firms in fewer countries in FY25 (13 different countries in FY25 vs

Research Stability Unlike sterile water for injection, the bacteriostatic formulation prevents degradation caused by bacterial contamination during repeated access critical for maintaining sample integrity across extended experiments

Martirosyan A, Clendening JW, Goard CA, Penn LZ

qRT-PCR was performed using the SYBR-green method as detailed in the Supplemental Methods