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Since redox imbalance is a mechanism involved in ME/CFS, it may be an indication of systemic inflammation in response to persistent infection or injury (251)

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Common symptoms signaling inflammation in reproductive tissues: Pelvic or testicular pain that persists beyond acute injury Irregular menstrual bleeding or heavy menses Painful intercourse or ejaculation Unexplained low-grade fever or malaise Changes in appetite, weight loss, or altered bowel habits Reduced sexual function or libido Treating inflammation upfront minimizes scarring, maintains error-free hormone signaling, and preserves fertility potential