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In some studies, methylfolate has reduced homocysteine by around 40 to 50% more than an equivalent dose of folic acid

Cancer Res 31, 19551961 (1971)

Wannemacher, R

That rationale must be backed by non-clinical data confirming the compound behaves as expected and by a thorough safety and toxicology program that identifies potential risks and establishes a safe starting dose for the first human administration and the maximum human exposure that should not be surpassed